Abstract:

Objective    The diabetic pig model was established by intravenous injection of streptozocin in order to investigate whether direct laser metal sintering（DLMS）could improve osseointegration in diabetic animal models. Methods    A diabetes model in mini-pigs was established by intravenous injection of streptozotocin（STZ）（150 mg/kg），and a total of 36 implants were inserted into the mandibular region. Micro-computed tomography（micro-CT）and histologic evaluations were performed three and six months after implantation. Results     The blood glucose level remained at high level（≥  10 mmol/L） after the induction of diabetes，reaching the diabetic level（≥ 7 mmol/L）. Obvious improvement in osseointegration was observed in the micro-CT and Van Gieson（VG）staining analyses of DLMS implants compared with MAO at three months（P < 0.05）， although this difference disappeared by six months（P > 0.05）. Conclusion    The rough surface of DLMS implants can accelerate the progress of osseointegration.

Key words: laser manufacturing, dental implants, diabetes mellitus, osseointegration

摘要：

目的    探索直接激光打印（DLMS）种植体在糖尿病小型猪模型中的早期骨结合情况。方法    以6只小型猪为研究对象，耳缘静脉一次性注射链脲佐菌素（STZ）水溶液150 mg/kg建立糖尿病模型，于糖尿病小型猪双侧上颌骨前磨牙区牙槽嵴顶植入DLMS及微弧氧化（MAO）种植体，并于3个月及6个月分别取材做微计算机断层（Micro-CT）扫描及组织学检查。结果    造模后小型猪血糖能稳定在较高水平（≥10 mmol/L），达到糖尿病标准（≥7 mmol/L）。Micro-CT及组织学检查可见，3个月时DLMS与MAO种植体骨结合差异有统计学意义（P＜0.05），6个月时两组之间差异无统计学意义（P＞0.05）。结论    DLMS种植体可加快糖尿病小型猪种植体骨结合速度。

关键词: 激光制造, 牙种植体, 糖尿病, 骨结合