Acta Metallurgica Sinica
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孙尚敏,闫露,潘亚萍,林莉,潘春玲,唐晓琳
基金资助:
辽宁省科学技术计划项目(2013225303)
Abstract:
Objective To explore the alveolar bone height changes in experimental type 1 diabetic rats. Methods Twelve male Sprague-Dawley (SD) rats were randomly divided into experimental and control groups. The rats in the experimental groups were made type 1 diabetes mellitus(DM)by intraperitoneal injection of streptozotocin (STZ) (60mg/kg),while the control groups were injected with equal volume citrate buffer. All animals were sacrificed after 8 weeks. The alveolar bone loss(ABL) of the first molar,second molar and the third molar were measured from alveolar crest to enamel-cementum junction by stereoscope loupe. Results The rats in the control groups had no obvious bone damage;while experimental groups showed obvious bone destruction horizontally, there was significant difference statistically(P<0.05). Conclusion The alveolar bone damage was shown in rats with type 1 diabetes mellitus,and was horizontal absorption slowly .
Key words: diabetes mellitus, DM;alveolar;streptozotocin, STZ
摘要:
目的 探讨实验性1型糖尿病大鼠牙槽骨高度的变化。方法 选取SPF级雄性Sprague-Dawley(SD)大鼠12只,随机分为实验组和对照组,每组6只。实验组大鼠腹腔一次性注射新鲜配制的链脲佐菌素(STZ)(60 mg/kg)建立1型糖尿病模型;对照组大鼠注射相应体积的柠檬酸盐缓冲液。观察8周,然后处死所有大鼠并分离其上下颌骨,体式显微镜观察测量上下颌骨第一、二、三磨牙的牙槽骨高度,比较分析牙槽骨高度的变化。结果 对照组大鼠未见明显的牙槽骨破坏;实验组大鼠可见明显的牙槽骨破坏,破坏呈水平型,第一、二、三磨牙牙槽骨均有破坏,与对照组相比差异有统计学意义(P<0.05)。结论 实验性1型糖尿病大鼠可见牙槽骨破坏,并且呈现缓慢的水平型吸收。
关键词: 糖尿病, 牙槽骨, 链脲佐菌素
孙尚敏,闫露,潘亚萍,林莉,潘春玲,唐晓琳. 实验性1型糖尿病大鼠牙槽骨高度变化研究[J]. 中国实用口腔科杂志, DOI: 10.19538/j.kq.2017.03.009.
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URL: http://www.zgsyz.com/zgsykqk/EN/10.19538/j.kq.2017.03.009
http://www.zgsyz.com/zgsykqk/EN/Y2017/V10/I3/171