关键词: 破骨细胞, 牙源性角化囊肿, 种植体周围炎, 牙周炎

Abstract: Bone homeostasis in the human body is mainly maintained by osteoblasts and osteoclasts. Once bone homeostasis is imbalanced，and bone resorption by osteoclasts exceeds osteogenesis of osteoblasts，there will be bone destruction diseases. Odontogenic keratocyst，peri-implantitis and periodontitis are common oral bone destruction diseases，and osteoclasts are closely related to them. This article reviews the research progress in the role of osteoclasts and their active factors in odontogeni keratocyst，peri-implantitis and periodontitis.

Key words: osteoclast, odontogenic keratocyst, peri-implantitis, periodondontitis