关键词: 浓缩生长因子, 干细胞, 细胞增殖, 成骨分化, 口腔颌面部缺损

Abstract: Concentrated growth factor（CGF），as the latest generation of platelet concentrates，is simple to prepare. It has a wide range of sources，high safety performance，and contains high concentrations of growth factors. It has a soft and thin fibrin network structure and can accelerate tissue regeneration. It is widely used to repair soft and hard tissue defects of oral and maxillofacial regions，and has gradually become a research hotspot of regenerative medicine and tissue engineering. Stem cells are a type of cells with multi-directional differentiation potential. After induction，they can be transformed into osteoblasts，which can promote bone tissue regeneration. Studies have confirmed that CGF can significantly promote stem cell proliferation and osteogenic differentiation. Therefore，this article summarizes the development history，main components and effects of CGF，the role of CGF on stem cell proliferation and osteogenic differentiation in the repair of oral and maxillofacial defects，and the summary and prospect. This review is aimed at providing new treatment ideas for oral and maxillofacial soft and hard tissue repair.

Key words: concentrated growth factor, CGF；stem cell；cell proliferation；osteogenic differentiation；oral and maxillofacial defect