关键词: 牙周膜, 组织工程, 机械负荷, 炎性环境

Abstract:

Periodontitis is a chronic infectious disease characterized by progressive destruction and loss of periodontium including gingiva，periodontal ligament，alveolar bone and cementum，and is the leading cause of tooth loss in adults. Clinically，periodontal tissues are generally recovered through surgical treatment under the control of inflammation，whereas periodontal ligament，also viewed as an interface between alveolar bone and cementum，is difficult to reconstruct for its complicated anatomy. With this context，this paper aims to discuss the structure and functions of natural periodontal ligament，the present technology of periodontal ligament regeneration and the specific factors influencing the regeneration. We wished to offer reference for periodontal regeneration.

Key words: periodontal ligament, tissue engineering, mechanical loading, inflammatory environment