关键词: 牙龈卟啉单胞菌, 植物提取物, 脂类, 抗菌肽, 金属纳米粒子, 群体感应抑制剂

Abstract: Porphyromonas gingivalis（P. gingivalis）is an important periodontal pathogen. The research and development of anti-bacterial agents against P. gingivalis is an important part of periodontal therapy. Traditional antibiotics may induce the antibiotic resistance and dysbacteriosis. Chemical anti-bacterial agents often cause side effects such as staining and taste change. New anti-bacterial agents can overcome the adverse effects and have obtained increasing attention. Recent studies have found that some new anti-bacterial agents have certain antibacterial effects on P. gingivalis，such as plant extracts，lipids，synthetic antimicrobial cationic peptides，metal nanoparticles，quorum sensing inhibitors，etc. These novel anti-bacterial agents can play their anti-bacterial roles by targeting bacterial cell membranes，biofilms，virulence factors，or quorum sensing systems. The antibacterial effects and related mechanisms of various new anti-bacterial agents against P. gingivalis will be reviewed in the article.

Key words: Porphyromonas gingivalis, P. gingivalis；plant extracts；lipids；antimicrobial cationic peptides；metal nanoparticles；quorum sensing inhibitors