关键词: 类风湿性关节炎, 牙周炎, 牙龈卟啉单胞菌, 牙龈卟啉单胞菌肽酰基精氨酸脱亚胺酶

Abstract:

Rheumatoid arthritis（RA）is a chronic autoimmunity inflammatory disease，characterized by joint damage，and periodontitis（PD）is a chronic inflammation of the supporting tissues surrounding the teeth. RA may increase the prevalence rate and severity of PD，and PD could? aggravate? the severity? of RA. There may be an association between PD and RA due to shared clinical and pathological manifestations，inflammation and immune response，genetic and environmental risk factors. Porphyromonas gingivalis is a leading pathogen in PD，which is the only bacterium known to express Porphyromonas gingivalis peptidyl-arginine deiminase（PPAD），and PPAD is a key factor in RA development. Hence，PPAD may be involved in the development of both diseases. This review will focus on the new progress of the ?correlation? and interaction mechanism between RA and PD.

Key words: rheumatoid arthritis, RA；periodontitis；Porphyromonas gingivalis；Porphyromonas gingivalis peptidyl-arginine deiminase, PPAD