关键词: 半导体激光, 牙龈瘤, 5-氟尿嘧啶

Abstract: Objective    To observe the clinical efficacy of semiconductor diode laser combined with 5-fluorouracil for epulis. Methods    Totally 38 patients who were diagnosed with epulis at the Stomatology Center of Shenzhen People′s Hospital from January 2017 to June 2018 were randomly divided into a group of simple semiconductor laser surgery （laser group）and a group of semiconductor laser combined with 5-fluorouracil treatment （laser combined 5-fluorouracil group），19 cases in each group. Follow-up was performed for 12 months, and the cure rate and recurrence of the two groups were compared. Results    In the laser combined with 5-fluorouracil group，19 cases were cured with a cure rate of 100%. Fifteen cases were cured in laser group and 4 cases recurred，and the cure rate was 78.9%. The difference in cure rate between the two groups was statistically significant（P = 0.035）. Postoperative pathological results of 38 patients were as follows：there were 26 cases of vascular epulis，8 cases of fibrous epulis and 4 cases of granulomatous epulis.  Conclusion    Epulis has a tendency to recur. Local injection of semiconductor diode laser combined with 5-fluorouracil has good therapeutic effect and can significantly reduce the recurrence rate of epulis，which is worthy of clinical promotion.

Key words: semiconductor diode laser, epulis, 5-fluorouracil