中国实用口腔科杂志

中国实用口腔科杂志

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钛合金种植体加载环形多肽生物涂层对早期骨结合影响研究

王卓琳1，李德超1，李慕勤2，刘苗1，吴倩1，焦玉凤2，李翀乾1，韩旭1   

  1. 1. 佳木斯大学附属口腔医院种植科，黑龙江  佳木斯  154000；2. 佳木斯大学材料科学与工程学院，黑龙江省高校生物医学材料重点实验室，黑龙江  佳木斯  154007
  • 出版日期:2018-04-15 发布日期:2018-04-17
  • 基金资助:

    国家自然科学基金（31370979）；佳木斯大学口腔医学预防与治疗协同创新中心（2011xtcx2016-02）

  • Online:2018-04-15 Published:2018-04-17

摘要：

目的    探讨超声微弧氧化技术与多巴胺化学偶联技术复合，在钛合金种植体表面构建环形多肽涂层对早期骨结合的影响。方法    钛合金种植体螺钉表面制备超声微弧氧化涂层（A组）、超声微弧氧化涂层表面多巴胺化学偶联（B组）及在B组基础上加载环形多肽涂层（C组），植入家兔下颌骨内，通过锥形束CT（CBCT）、扫描电镜、能谱分析仪、扭力实验来观察3组不同涂层种植体的早期成骨情况。结果    CBCT显示，植入8周时C组种植体周围骨密度明显高于A、B两组。扫描电镜及能谱分析仪观察表明，C组种植体表面膜层变厚，新生骨明显增加，且C组种植体表面增加了利于骨生长的Ca、P元素。扭力实验表明，种植体植入8周时C组的扭力值明显高于A、B两组，且差异有统计学意义（P < 0.05）。结论    在钛合金种植体表面加载环形多肽的复合膜层对早期成骨有明显的促进作用。

关键词: 钛合金, 种植体, 超声微弧氧化, 多巴胺, 环形多肽

Abstract:

Objective    To discuss the effect of ultrasonic microarc oxidation-dopamine-cyclo polypeptides on the surface of titanium alloy implants on early bone binding. Methods    The specimens were divided into 3 groups：titanium alloy ultrasonic microarc oxidation（group A），titanium alloy ultrasonic microarc oxidation-dopamine（group B）and titanium alloy ultrasonic microarc oxidation-dopamine-cyclo polypeptides（group C）. Implants were installed into the maxilla inferior area of rabbits. To observe the early osteogenesis responses of 3 groups by general observation，CBCT examination，scanning electron microscopy，energy spectrum analyzer and torsion experiment were performed. Results    CBCT showed that the bone density of group C was higher than group A and group B in 8 weeks. Scanning electron microscopy and the energy spectrum analyzer showed that the panniculus of group C increased and new bones rised，and the composite coating increased the Ca and P elements that were beneficial to bone growth. Torsion experiment indicated that the torsion was the highest in group C compared to group A and group B at post-operative 8 weeks，the experiments showing significant differences（P < 0.05）. Conclusion    Titanium alloy implants with ultrasonic microarc oxidation-dopamine-cyclo polypeptides coating can promote early osteogenesis.

Key words: titanium alloy, implants, ultrasonic microarc oxidation, dopamine, cyclo polypeptides