关键词: 慢性牙周炎, 牙周基础治疗, 超敏C反应蛋白, 单核细胞趋化蛋白-1

Abstract:

Objective    This study compared circulating high-sensitivity C-reactive protein（hs-CRP）and monocyte chemoattractantprotein-1（MCP-1）in control individuals and patients with periodontal disease and observed whether non-surgical periodontal therapy affected inflammatory disease markers after 3 months. Methods    40 controls and 80 patients with periodontal disease were selected.Periodontal parameters included probing depth，bleeding on probing，clinical attachment level， as well as the following inflammatory markers：high-sensitivity C-reactive protein （hs-CRP）and monocyte chemoattractant protein（MCP）-1. Results    There were no differences in the hematologic parameters of the patients in the control and periodontal disease groups. Hs-CRP and MCP-1 concentrations were higher in theperiodontal disease group at baseline compared to the controls（P = 0.005 and P = 0.003，respectively）. A decrease in circulating hs-CRP and MCP-1 concentrations was observed 3 months after therapy（P = 0.009 and P = 0.007，respectively）. Conclusion    In apparently otherwise healthy patients，periodontal disease is associated with increased circulating concentrations of hs-CRP andMCP-1，which decreased 3 months after non-surgical periodontal therapy.

Key words: chronic periodontitis, periodontal therapy, high-sensitivity C-reactive protein, monocyte chemoattractant protein-1