关键词: 趋化因子, 牙周炎, 牙龈沟液

Abstract:

Objective    To explore the relationship between chronic periodontitis and cytokine interleukin-8 （IL-8） by literature review. Methods    The CNKI，Wanfang database，PubMed retrieval platform and Embase database were searched by computer. The research papers on the level of interleukin-8 in chronic periodontitis were collected. The retrieval time was up to 2016；screen literature according to the inclusion and exclusion criteria；use Stata12.0 software for meta analysis. Results    The level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was significantly higher than that in normal controls（P＜0.05）. In the Asian population， the level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was higher than that in normal controls（P＜0.05）. In the western population，there was no difference in the level of IL-8 in gingival crevicular fluid between patients with chronic periodontitis and normal controls（P＞0.05）. Conclusion    There is a significant difference in chemokines interleukin-8 between patients with chronic periodontitis and normal controls in the Asian population. Chemokines interleukin-8 may increase the risk of chronic periodontitis.

Key words: chemokines, periodontitis, gingival crevicular fluid