Chinese Journal of Practical Pediatrics

Chinese Journal of Practical Pediatrics ›› 2022, Vol. 37 ›› Issue (5): 372-378.DOI: 10.19538/j.ek2022050612

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Study on the ageand genderspecific reference intervals of trace elements and the relationship among the trace elements in children aged 10 to 12 years in Chongqing

  

  1. *Department of Clinical Epidemiology and Biostatistics，Childrens Hospital of Chongqing Medical University，National Clinical Research Center for Child Health and Disorders，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Pediatrics，Chongqing  400014，China
  • Online:2022-05-06 Published:2022-07-14

重庆市10～12岁儿童年龄别与性别别微量元素参考值与微量元素之间相关性研究

  

  1. 1.重庆医科大学附属儿童医院儿科研究所临床流行病与生物信息学室 儿童发育疾病研究教育部重点实验室 国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地 儿科学重庆市重点实验室，重庆  400014；2.重庆市中医院检验科 重庆市中医院感染性疾病中西医结合诊治实验室，重庆  400021
  • 通讯作者: 梁小华，电子信箱：xiaohualiang@hospital.cqmu.edu.cn
  • 基金资助:
    国家自然科学基金青年基金（81502826）；重庆市科学技术委员会重点课题（CSTC2021jscx-gksb-N0001）；重庆医科大学未来医学青年创新团队项目（W0088）；重庆市科卫联合项目（2020FYYX060）；科技部国家重点研发计划课题（2017YFC0211705）；重庆市教育委员会项目（KJQN201900443）

Abstract: Objective　This study aims to discuss the reference intervals of trace elements and the relationships among trace elements in children aged 10-12 years in Chongqing. Methods　Stratified cluster sampling was used to include 2058 children aged 10-12 years from urban and rural areas of Chongqing. Venous blood was collected and trace element levels in whole venous blood were measured. Non-parametric reference value estimation method was used to calculate the reference value of trace elements，and generalized linear regression model was used to analyze the relationships among trace elements. Results　The study showed that total reference intervals of Ca，Zn，Mg，Cu and Fe were 1.35-2.13 mmol/L，56.42-107.0 μmol/L，1.23-1.81mmol/L，8.25-22.37 μmol/L and 6.14-9.45 mmol/L，respectively. The levels of Mg，Cu and Fe in girls were lower than those in boys（P<0.05）；the levels of Zn and Cu in urban were higher than those in rural children，and their levels of Ca，Mg and Fe were lower than those in rural children （P<0.01）.The levels of Ca and Cu decreased with the increase of age，while the levels of Zn，Mg and Fe increased with the increase of age. The generalized linear regression model showed that there were significant relationships among Ca，Zn，Mg，Cu and Fe （P<0.01）. Conclusion　The study has established the age- and gender-specific reference intervals of Ca，Zn，Mg，Cu and Fe of adolescent. Besides，age，gender and urban-rural areas have significant impact on trace element levels，which should be taken into account in the prevention and treatment of childrens nutritional diseases.

Key words: adolescent, trace elements, reference intervals, relationship

摘要： 目的　探讨重庆地区10～12岁儿童微量元素参考值范围及微量元素间的相关关系。方法　采取分层整群抽样方法在重庆城乡地区抽取10～12岁儿童2058例，采集静脉血，测量静脉全血微量元素水平。采用非参数参考值估计方法计算儿童微量元素参考值，并采用广义线性回归模型分析微量元素间的相关关系。结果　研究结果表明钙（Ca）、锌（Zn）、镁（Mg）、铜（Cu）和铁（Fe）的总体参考值范围分别为1.35～2.13 mmol/L，56.42～107.00 μmol/L，1.23～1.81 mmol/L，8.25～22.37 μmol/L和6.14～9.45mmol/L。女性儿童Mg、Cu和Fe的水平均低于男性儿童（P<0.05），城市儿童Zn和Cu的水平高于农村儿童，Ca、Mg和Fe的水平低于农村儿童（P<0.01）。Ca和Cu的水平随着年龄的增加呈现降低的趋势，Zn、Mg和Fe的水平随着年龄的增加呈现增加的趋势。广义线性回归模型显示Ca、Zn、Mg、Cu和Fe五种微量元素间均存在显著的相关关系（P<0.01）。结论　该研究建立了青春期儿童年龄-性别别Ca、Zn、Mg、Cu和Fe的参考值范围。此外，年龄、性别与城乡地区均对微量元素水平有显著的影响，儿童营养性疾病的防治应考虑年龄、性别及城乡地区的差异。

关键词: 青少年, 微量元素, 参考值, 相关关系