Abstract:

Objective    To explore the clinical features of infective endocarditis and the factors related to efficacy. Methods    The clinical data of 33 patients with infective endocarditis admitted to our hospital from november 2013 to november 2015 were retrospectively analyzed，including the pathogenic characteristics，underlying diseases，vegetation distributions，treatment program and prognosis. Results    The pathogen detection rate of those cases was 75.76%，and the rate of being with underlying disease was 93.94%. The vegetation laid mainly in the heart valves（63.64%），followed by implant artificial material，the impact place of residual shunt and blood flow. For all the cases，the combination of the surgery with the full course of antibiotic therapy had good effect. Conclusion    The positive blood culture in patients of infective endocarditis is high. The disease is more common in children with basic heart diseases. The combination of the early radical surgery and the full course of antibiotic therapy are the key to the treatments.

Key words: infective endocarditis, child, congenital heart disease, etiology, vegetation

摘要：

目的    探讨儿童感染性心内膜炎的临床特点及影响疗效的因素。方法    回顾性研究2013年11月至2015年11月上海儿童医学中心心内科诊断并治疗的33例感染性心内膜炎患儿的临床资料，分析其病原学特点、心脏基础疾病、赘生物分布特点、治疗方案及预后情况。结果    感染性心内膜炎病原菌的检出率为75.76%。具有先天性心脏基础疾病的比例为93.94%。赘生物主要位于反流的瓣膜，占63.64%，其次为植入的人工材料、缺损处分流及血流冲击处等。手术结合足疗程的抗感染治疗效果较好。结论    感染性心内膜炎的血培养阳性率高，且多发生于具有心脏基础疾病的患儿。早期彻底的手术治疗联合全程抗感染治疗是治疗感染性心内膜炎的关键。

关键词: 感染性心内膜炎, 儿童, 先天性心脏病, 病原学, 赘生物