Abstract: Sepsis is a life-threatening organ dysfunction caused by the body’s dysfunctional response to infection. There is currently no definitive symptomatic treatment for sepsis inflammatory response in the clinic. Blood purification treatment exerts immunomodulatory effects by non-specifically eliminating endotoxin and/or inflammatory mediators and shows a good prospect of application in sepsis. However，most studies on the treatment of sepsis with blood purification have not shown significant improvement in patients’ prognosis. This article reviews the research progress of immunoregulation mechanism of blood purification therapy for sepsis，as well as the advantages and disadvantages of different blood purification methods.

Key words: sepsis, blood purification, therapy

摘要： 脓毒症是机体对感染反应失调而引起的危及生命的器官功能障碍。目前临床上尚无针对脓毒症炎性反应的确切对症治疗方法。血液净化治疗通过非特异性清除内毒素和（或）炎症介质而发挥免疫调理作用，显示出良好的应用前景。然而目前多数有关血液净化治疗脓毒症的研究结果并未显示其可以明显改善患者预后。该文就脓毒症血液净化免疫调节机制及不同血液净化方法利弊的研究进展进行介绍。

关键词: 脓毒症, 血液净化, 治疗