Abstract:

Hypercalcemia in children has often been in lack of specific clinical symptoms and is not easy to be found. PTH dependent hypercalcemia and non-PTH dependent hypercalcemia is classified based on the serum parathyroid hormone（PTH） level in hypercalcemia children. Primary hyperparathyroidism is the main cause of PTH dependent hypercalcemia in children. Etiology of hypercalcemia in children is complicated，and in the newborn and infants it’s mainly iatrogenic and common genetic factors；children and adolescents，the primary hyperparathyroidism is the main factor. Clinical diagnosis can be made according to symptoms/ signs，serum PTH，parathyroid hormone-related proteins，vitamin D metabolites and other laboratory indexes.

Key words: hypercalcemia, primary hyperparathyroidism, vitamin D, parathyroid hormone（PTH）, child

摘要：

儿童高钙血症常缺乏特异性临床症状，不易被发现。根据血清甲状旁腺激素（PTH）的水平，可分为PTH依赖性和非PTH依赖性高钙血症，前者以原发性甲状旁腺功能亢进为主。儿童高钙血症病因复杂：新生儿及婴儿期主要病因为医源性及遗传性；儿童青少年则以原发性甲状旁腺功能亢进为主。临床上可根据症状、体征和血清PTH、PTH相关蛋白、维生素D代谢产物等实验室指标进行诊断分析。

关键词: 高钙血症, 原发性甲状旁腺功能亢进, 维生素D, 甲状旁腺激素, 儿童