中国实用儿科杂志

中国实用儿科杂志 ›› 2022, Vol. 37 ›› Issue (1): 21-24.DOI: 10.19538/j.ek2022010605

• 专题笔谈 • 上一篇    下一篇

儿童IgA血管炎肾损伤监测 与早期生物标记物

  

  1. 国家儿童医学中心  复旦大学附属儿科医院肾脏科，上海  201102
  • 出版日期:2022-01-06 发布日期:2022-02-19

Monitoring and early biomarkers of kidney injury in children with IgA vasculitis

  1. Department of Nephrology，Children’s Hospital of Fudan University，National Children’s Medical Center，Shanghai  201102
  • Online:2022-01-06 Published:2022-02-19

摘要： IgA血管炎（IgA vasculitis，IgAV）是儿童期最常见的小血管炎，约40%～50%患儿可累及肾脏，其中部分可进展至慢性肾衰竭，最终导致终末期肾病，严重影响患儿及其家庭生活质量。目前肾活检病理检查仍是判断IgAV肾损伤程度的金标准，然而因其创伤性大、不易动态监测等，迫切需要探究无创、更易获得的检测指标。近年来，随着蛋白组学及分子基因学进步，探究尿液及血清标本中儿童IgAV肾损害的生物标志物日益受到关注。故现将相关研究作一综述。

关键词: IgA血管炎, 过敏性紫癜性肾炎, 生物标志物, 儿童 

Abstract: IgA vasculitis is the most common vasculitis of small vessels in children，about 40%～50% involving kidney，which partly could develop into chronic kidney failure，even end-stage kidney disease，and seriously affects life quality of children and their families. Currently，the golden standard to diagnose and evaluate IgAV kidney damage is kidney biopsy，which is invasive and not easy for dynamic monitoring，and this forces us to find noninvasive and more accessible ways. Recently，with the progress of proteomics and molecular biological research，more attention is paid to urine and blood biomarkers which predict kidney damage in children with IgAV. This article reviews the related research progress.

Key words: IgA vasculitis, Henoch-seh?nlein purpura nephritis, biomarker, child