关键词: IgA血管炎肾损伤, IgA肾病, 儿童 

Abstract:

The first description of IgA vasculitis with nephritis was reported about 160 years earlier than that of IgA nephropathy. The diagnosis of IgA vasculitis with nephritis is typically based on the clinical manifestation，where as IgA nephropathy can only be diagnosed by a kidney biopsy. Some recent studies have demonstrated the similarities in the pathogenesis，genesis，clinical manifestations，pathological characteristics between the two diseases，and treatment，but there are some differences in terms of out come and age at onset，and the fact that not all the patients with IgA vasculitis have renal involvement，and skin manifestations do not occur in patients with IgA nephropathy，which indicates these two entities need to be differentiated. There is insufficient evidence to support the hypothesis that IgA vasculitis with nephritis and IgA nephropathy are two clinical presentations of the same disease.

Key words: IgA , vasculitis with nephritis, IgA , nephropathy, children