中国实用儿科杂志

中国实用儿科杂志 ›› 2021, Vol. 36 ›› Issue (11): 842-848.DOI: 10.19538/j.ek2021110609

• 党为人民谋健康的 100 年·专题笔谈 • 上一篇    下一篇

儿童系统性红斑狼疮与肾炎慢病管理及治疗进展

  

  1. 贵阳市妇幼保健院  贵阳市儿童医院风湿免疫科，贵州  贵阳  550003
  • 出版日期:2021-11-06 发布日期:2022-01-04
  • 通讯作者: 邵晓珊，电子信箱：sxs22@qq.com

Advances in chronic disease management and Treatment of cSLE and LN

  1. Department of Renal Rheumatology，Guiyang Children's Hospital，Guiyang  550003，China
  • Online:2021-11-06 Published:2022-01-04

摘要： 儿童系统性红斑狼疮（childhood-onset systemic lupus erythematosus，cSLE）是特指在18岁之前发病的系统性红斑狼疮。可累积全身多脏器、多系统，有多达60%的患儿会出现狼疮性肾炎（lupus nephritis，LN），其中19%的患儿进展为终末期肾病。感染和终末期肾病是导致发展中国家cSLE死亡的常见原因。由于疾病本身和治疗都会影响患儿的身心和生长发育，做好cSLE与LN的慢病管理对控制病情、提高长期生存率极为重要。本文总结了近年来国内外系统性红斑狼疮慢病管理的经验，并对cSLE与LN慢病管理和治疗进展进行综述，旨在提高治疗达标率，减少疾病复发及并发症的发生，使患儿获益。

关键词: 系统性红斑狼疮, 狼疮性肾炎, 慢病管理, 治疗, 儿童

Abstract: Childhood- onset systemic lupus erythematosus（cSLE） refers to SLE that develops before the age of 18 years. It involves multiple organs and systems throughout the body. Up to 60% of these children will develop Lupus Nephritis（LN），with 19% of whom progresses to end-stage renal disease. Infection and end-stage renal disease are the main causes of death in cSLE of developing countries. As both the disease itself and the treatment affect the physical and psychological growth and development of children，a well-conducted chronic disease management is extremely important for the disease control and long-term survival of children with cSLE and LN. This article summarised the experience in SLE chronic disease management at home and abroad in recent years，and reviewed chronic disease management and treatment progress of cSLE and LN ，with the aim of improving the attainment rate and reducing the occurrence of disease relapse and complications in order to benefit the children.

Key words: systemic lupus erythematosus, lupus nephritis, chronic disease management, treatment, child