关键词: 慢性肾脏病, 儿童, 营养, 肾小球滤过率

Abstract:

Abstracts： Objective To evaluate the nutritional status and the factors related to nutrition in children with chronic kidney disease（CKD）. To explore the biological monitoring index of nutritional status of children with CKD. Methods Totally 123 patients with CKD hospitalized in our hospital from 2009 to the end of 2011 were enrolled in this study. Another 168 healthy children were chosen as control group. The height，weight，and insulin-like growth factor binding proteins 3 （IGFBP3） of the two groups were measured. The median percentage of weight for age（W/A），height for age （H/A）and weight for height （W/H）， BMI and glomerular filtration rate （GFR） were also calculated. The nutritional status was assessed according to the methods recommended by American Academy of Pediatrics. The relationship between the nutritional status and GFR， gender as well as the duration of CKD were analyzed. Nutritional knowledge questionnaire for parents of children in CKD group was taken. Results The levels of W/A in 70（56.91%）， H/A in 63（51.22%） and W/H in 60 （48.78%） children with CKD were lower than that of the control group（χ2=78.676，41.853，39.281， P=0.000）， and were positively correlated with the glomerular filtration rate （r=0.552，0.368，0.539； P=0.000）. The serum levels of IGFBP3 were much higher than the control’s（t=2.725， P=0.008）. The number of overweight and obesity was 21 cases （17.07%）. About 76.67% parents of children with CKD had no knowledge of nutrition. Conclusion Malnutrition is the common complication in CKD children.The nutritional status in CKD children is positively related to the glomerular filtration rate. Serum IGFBP3 and GFR can be the biological monitoring index of nutritional status. Obesity in CKD children can’t be ignored.It is important to guide and popularize knowledge of nutrition periodically.