中国实用儿科杂志

中国实用儿科杂志

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输血相关的循环超负荷及急性肺损伤

  

  1. 重庆医科大学附属儿童医院重症医学科， 重庆 401122
  • 出版日期:2020-12-06 发布日期:2021-01-14

Transfusion-associated circulatory overload and transfusion-related acute lung injury

  1. Department of Intensive Medicine，Affiliated Children’s Hospital of Chongqing Medical University，Chongqing  401122，China
  • Online:2020-12-06 Published:2021-01-14

摘要： 输血相关的循环超负荷（transfusion-associated circulatory overload，TACO）和输血相关的急性肺损伤（transfusion-related acute lung injury，TRALI）是大型外科手术中和重症监护病房危重症患儿常见的致死性输血并发症。TACO的特征是心源性肺水肿，而TRALI则主要为非心源性ARDS，二者在临床可能重叠出现，要将其清楚地区分比较困难。目前还没有特异性治疗方法。该文简述TACO和TRALI的概念、流行病学、病理生理、临床表现、诊断及可能的防治措施。

关键词: 输血, 循环超负荷, 急性肺损伤, 危重症

Abstract: Transfusion-associated circulatory overload（TACO） and transfusion-related acute lung injury（TRALI） are common fatal complications in major surgery and the intensive care unit. TACO is characterized by cardiogenic（non-inflammatory） pulmonary edema，and TRALI is characterized by non-cardiogenic pulmonary edema. However，they have overlapping features，which makes the differentiation between the two difficult. There has been no specific treatment up to now. In this article，we briefly describe the concepts，epidemiology，pathophysiology，clinical features，diagnosis，and possible prevention and management of TACO and TRALI.

Key words: transfusion, circulatory overload, acute lung injury, critical illness