中国实用儿科杂志

中国实用儿科杂志

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输血相关性移植物抗宿主病

  

  1. 上海交通大学医学院附属上海儿童医学中心重症医学科，上海  200127
  • 出版日期:2020-12-06 发布日期:2021-01-14

Transfusion-associated graft-versus-host disease

  1. Department of Pediatric Intensive Care Unit，Shanghai Children’s Medical Center，Shanghai Jiaotong University School of Medicine，Shanghai  200127，China
  • Online:2020-12-06 Published:2021-01-14

摘要： 输血相关移植物抗宿主病（TA-GVHD）是一种罕见且致命的输血并发症。主要发病机制可能为供者T淋巴细胞在受者体内增殖并攻击自身组织器官从而引起严重的临床症状，包括全血细胞减少及多器官（如皮肤、肝脏、胃肠道等）功能损害。目前缺乏有效的治疗手段。其主要预防手段为对特定人群输注γ射线照射血制品，另外病毒灭活技术也有良好的应用前景。该文主要对TA-GVHD的发病机制、临床表现、诊断、治疗及预防进行系统阐述。

关键词: 输血, 移植物抗宿主病, 免疫功能不全, &gamma, 照射

Abstract: Transfusion-associated graft-versus-host disease is a rare and fatal complication of blood transfusion. The possible main pathogenesis includes that donor T lymphocyte proliferation in blood，their engraftment and immune attack on tissues and organs of recipients. The main clinical features of TA-GVHD are pancytopenia and multiorgan failure（skin，liver，gastrointestinal tract，etc）. At present，there is no effective treatment for this disease. Currently，exposure of blood products to γ irradiation is commonly recognized prevention of TA-GVHD，and pathogen inactivation（PI） technology may be an alternative method. In this report，we mainly discuss the pathogenesis clinical characteristics，diagnosis and prevention.

Key words: transfusion；graft-versus-host disease（GVHD）；immunocompromised；&gamma, irradiation