中国实用儿科杂志

中国实用儿科杂志

• 专题笔谈 • 上一篇    下一篇

儿童自主神经介导性晕厥遗传学研究进展

  

  1. 上海交通大学附属儿童医院，上海  200240
  • 出版日期:2016-08-06 发布日期:2016-08-02

Recent advances in genetic research into neurally mediated syncope in children

  1. Children’s Hospital of Shanghai，Shanghai Jiao Tong University，Shanghai  200240，China
  • Online:2016-08-06 Published:2016-08-02

摘要：

儿童自主神经介导性晕厥（neurally mediated syncope，NMS）是最常见的晕厥类型，NMS的确切发病机制目前仍不详，根据其在家族中有簇集性发病的特点，提示有遗传学机制参与。近年来，NMS遗传学研究主要集中在与异常心血管反射相关的自主神经系统及其神经递质、血管活性分子等候选基因多态性、家族史研究和双胞胎研究方面等。

关键词: 神经介导性晕厥, 遗传学, 儿童

Abstract:

Neurally mediated syncope（NMS）is the most common type of syncope，whose exact pathogenesis is still unknown. The characteristics of family cluster show that NMS has a genetic mechanism. In recent years，genetic researches of NMS are mainly concentrated on the candidate gene polymorphisms of autonomic nervous system，neurotransmitter and vasoactive molecules，family history and twin study.

Key words: neurally mediated syncope, genetics, child