中国实用儿科杂志

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儿童自身免疫性脑炎

吴革菲刘智胜   

  1. 作者单位:武汉市儿童医院神经内科, 湖北 武汉 430016
  • 出版日期:2014-07-06 发布日期:2014-06-26
  • 通讯作者: 刘智胜 

Autoimmune encephalitis in children.

WU Ge-feiLIU Zhi-sheng.   

  1. Department of Neurology,Wuhan Children’s Hospital,Wuhan 430016,China
  • Online:2014-07-06 Published:2014-06-26

摘要:

儿童自身免疫性脑炎是由作用于神经元蛋白并影响神经递质传递及兴奋性的自身免疫性抗体所致。临床以抗N-甲基-D-天门冬氨酸 (N-methyl-D-aspartate,NMDA)受体脑炎和自身免疫性边缘叶脑炎最常见。儿童自身免疫性脑炎临床诊断主要依据临床表现、影像学检查、血液和(或)脑脊液抗体检测。糖皮质激素、丙种球蛋白和血浆置换是目前的一线治疗手段。重在早期诊断和早期免疫治疗,部分患儿预后良好。

关键词: 自身免疫性脑炎, 抗NMDA受体脑炎, 自身免疫性边缘叶脑炎, 儿童

Abstract:

Abstracts: Child autoimmune encephalitis is characterized by autoimmune antibodies specifically against neuronal proteins and affecting neurotransmitters and excitability. Clinically the most common autoimmune encephalitides are anti-NMDA receptor encephalitis and autoimmune limbic encephalitis. Diagnosis of child autoimmune encephalitis is mainly based on clinical manifestations, imaging examination, detection of autoimmune antibodies in blood and/or cerebrospinal fluid. Corticosteroids and gamma globulin and plasma exchange are the first-line treatment. Early diagnosis and early start of immunotherapy will lead to a good prognosis in some children with autoimmune encephalitis.

Key words: autoimmune encephalitis, anti-NMDA receptor encephalitis, autoimmune limbic encephalitis, children

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