关键词: 儿童, 高胆红素血症, 胆汁淤积

Abstract: Hyperbilirubinemia in children often presents with jaundice，which is a common symptom in children，especially in infants and young children.Jaundice can be caused by a variety of pathophysiological，anatomical，infectious and autoimmune diseases，as well as genetic metabolic factors and diseases.Different causes of jaundice have different severity，prognosis，timing for treatment and plan for treatment.It is essential for patients to be diagnosed earlier and receive individualized treetment.With the development of molecular detection technology，Next-generation sequencing technology allows us to quickly and effectively make molecular diagnosis of diseases that cannot be directly diagnosed through conventional blood tests or liver biopsies，and then precise treatment can be given.This article mainly introduces the common causes of hyperbilirubinemia in children and their diagnosis and treatment strategies.

Key words: child, hyperbilirubinemia, cholestasis