中国实用儿科杂志

中国实用儿科杂志 ›› 2022, Vol. 37 ›› Issue (7): 496-500.DOI: 10.19538/j.ek2022070605

• “一切为了人民健康———我们这十年”专栏·专题笔谈 • 上一篇    下一篇

儿童药物性肝损伤的诊断与鉴别诊断

  

  1. 解放军总医院第五医学中心，北京  100039
  • 出版日期:2022-07-06 发布日期:2022-08-25
  • 通讯作者: 朱世殊，电子信箱：302zss@sina. com

Diagnosis and differential diagnosis of drug-induced liver injury in children

  1. 5th Medical Center，PLA General Hospital，Beijing  100039，China
  • Online:2022-07-06 Published:2022-08-25

摘要： 儿童药物性肝损伤目前没有客观、特异的诊断方法，仍需要依靠明确的用药史、药物与肝损伤之间的关联、可疑药物再暴露试验阳性、肝脏病理，尤其是要除外其他肝病才能确诊。亟待开发特异性及敏感性更高的新型生物标记物。

关键词: 药物性肝损伤, 儿童, 诊断, 生物标志物

Abstract: At present，there is no objective and specific diagnostic method for drug-induced liver injury in children，which still needs to be confirmed by clear medication history，association between drugs and liver injury，positive test of reexposure to suspected drugs and liver pathology，especially excluding other liver diseases.It is urgent to develop new biomarkers with higher specificity and sensitivity.

Key words: drug-induced liver injury, child, diagnosis, biomarkers