中国实用儿科杂志

中国实用儿科杂志

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儿童呼吸道感染博卡病毒流行病学特征分析

  

  1. 苏州大学附属儿童医院呼吸科，江苏  苏州  215003
  • 出版日期:2018-06-06 发布日期:2018-06-11

Epidemiological features of human bocavirus in children with respiratory tract infection

  1. Department of Respiratory Diseases，Children’s Hospital of Soochow University，Suzhou  215003，China
  • Online:2018-06-06 Published:2018-06-11

摘要：

目的　分析儿童呼吸道感染博卡病毒（human bocavirus， HBoV）流行病学特征， 为临床合理诊治提供参考依据。方法　收集2009年1月至2016年12月在苏州大学附属儿童医院呼吸科住院治疗的16 913例呼吸道感染患儿的痰标本和临床资料，采用实时荧光定量PCR法检测HBoV，分析HBoV检出情况。结果　16 913例患儿中，HBoV阳性检出率为5.16%（873/16913例）。男性患儿HBoV阳性检出率为5.42%（573/10566例），女性患儿为4.73%（300/6347例），男性患儿HBoV检出率高于女性患儿（χ2＝3.928，P＝0.047）。＜1岁、 ～3岁、～7岁以及≥7岁患儿的HBoV检出率分别为4.03%（325/7963例）、8.75%（401/4584例）、3.99%（134/3357例）、1.29%（13/1009例）， 各年龄组HBoV检出率差异有统计学意义（χ2＝182.075， P＜0.01）。春夏秋冬四季HBoV阳性检出率分别为3.36%（146/4341例）、 6.92%（295/4261例）、 6.88%（287/4172例）、 3.50%（145/4139例）， 夏秋季患儿HBoV阳性检出率明显高于冬春季（χ2＝93.801， P＜0.01）。结论　苏州大学附属儿童医院2009年1月至2016年12月呼吸道感染患儿HBoV检出率为5.16%， 幼儿HBoV检出率高， 男性患儿高于女性。夏秋季为HBoV感染的高发季节。

关键词: 博卡病毒, 呼吸道感染, 流行病学, 儿童

Abstract:

Objective　To analyze the epidemiological characteristics of human bocavirus（HBoV） infection in children with respiratory tract diseases，and to provide scientific basis for clinical diagnosis and treatment. Methods　Sputum specimens and clinical informations of 16 913 cases of hospitalized children with respiratory tract diseases from January 2009 to December 2016 in Children’s Hospital of Soochow University were collected. HBoV DNA was detected by fluorescence quantitative polymerase chain reaction at real time to analyze the detections. Results　The HBoV detection rate was 5.16%（873/16 913 cases） in 16 913 children. The HBoV detection rate of boys was 5.42%（573/10 566 cases），which was significantly higher than that of girls［4.73%（300/6 347 cases），χ2＝3.928，P＝0.047］. The HBoV detection rate of children at the age of less than 1 year old，-3 years old，-7 years old and older than 7 years old were 4.03%，8.75%，3.99% and 1.29%，respectively，the difference of which had statistical significance（χ2＝182.075，P＜0.01）. The HBoV detection rate in spring, summer，autumn and winter were 3.36%（146/4341 cases），6.92%（295/4261 cases），6.88%（287/4172 cases） and 3.50%（145/4139 cases），respectively. The HBoV detection rate in summer and autumn was significantly higher than that in spring and winter（χ2＝93.801，P＜0.01）. Conclusions　The HBoV detection rate in children with respiratory tract diseases is 5.16% in Suzhou area from Jan. 2009 to Dec. 2016. The highest HBoV detection rate is high in infant，especially in boys. Epidemical seasons of HBoV infection in Suzhou are summer and autumn.

Key words: bocavirus, respiratory tract infectoion, epidemiology, child