中国实用儿科杂志

中国实用儿科杂志

• 专题笔谈 • 上一篇    下一篇

益生菌在抗儿童幽门螺杆菌感染中的应用

  

  1. 昆明医科大学第一附属医院儿科,云南  昆明  650032
  • 出版日期:2017-02-06 发布日期:2017-02-06

Probiotics in treatment of children with Helicobacter pylori infection

  1. Department of Pediatrics，First Affiliated Hospital of Kunming Medical University，Kunming  650032，China
  • Online:2017-02-06 Published:2017-02-06

摘要：

幽门螺杆菌（helicobacter pylori，Hp）感染率高，致病性强，根除Hp有其临床意义。标准三联疗法（一种质子泵抑制剂＋两种抗生素）或是含铋剂的三联（胶体铋+阿莫西林+咪唑类）、四联疗法（质子泵抑制剂+阿莫西林+甲硝唑+胶体铋）都是目前公认的根除儿童Hp的方案。但由于Hp对抗生素耐药率的逐年升高，根除率已明显降低。近年来，益生菌在根除Hp治疗中的作用受到了重视，该文综述了益生菌在提高儿童Hp根除率中可能的机制，以及在减少Hp根除过程中不良反应的优势。

关键词: 益生菌, 幽门螺杆菌, 儿童, 根除率, 不良反应

Abstract:

Helicobacter pylori（Hp） infection rate is high and has strong pathogenicity，so the eradication of Hp has great significance. The combination of a proton pump inhibitor with two antibiotics，or bismuth-based triple therapy or quadruple therapy is recommended as a alternate first-line regimen for treating Hp infection in children. In recent years，the success of eradication therapies has declined，party due to the increassing rate of Hp resistant strains. Hp eradication therapy with probiotics has received more and more attention. In this article，we comprehensively review the possible mechanisms of probiotics in treating Hp infection in children，and its advantage in the prevention of antibiotic-associated side effects is also discussed.

Key words: probiotics, Hp, child, eradication rate, side effects