中国实用外科杂志 ›› 2025, Vol. 45 ›› Issue (03): 356-360.DOI: 10.19538/j.cjps.issn1005-2208.2025.03.22

• 文献综述 • 上一篇    

十二指肠残端瘘预防及诊治进展

郑    煌,Joshua Lin,邵岩飞,周雪亮,郑民华,孙    晶   

  1. 上海交通大学医学院附属瑞金医院普外科 上海市微创外科临床医学中心,上海200025
  • 出版日期:2025-03-01 发布日期:2025-03-27

  • Online:2025-03-01 Published:2025-03-27

摘要: 十二指肠残端瘘是胃切除术后常见且严重的并发症,尤其在Billroth Ⅱ式和Roux-en-Y重建术后更为多见。其主要表现为上腹疼痛、发热、心率加快等,严重时可导致腹膜炎、腹腔感染及休克等危及生命的并发症。诊断依赖影像学检查,如CT和超声等。该病的危险因素包括年龄、性别、营养不良、低白蛋白血症、肝硬化以及胃肿瘤部位等。特别是胃窦和幽门部位的肿瘤更易导致残端瘘的发生。十二指肠残端瘘的早期诊断和干预非常关键。轻症病人可仅行保守治疗,如禁食、胃肠减压、抗生素及营养支持等;对于症状严重的病人,则需手术干预。内镜治疗对于较小、无明显感染的瘘有一定优势,而开放手术治疗则针对较重的病例。尽管十二指肠残端瘘的发生率较低,但若处理不当可能导致严重后果,需根据病人具体情况制定个体化治疗方案,以提高治疗效果和病人的预后。

关键词: 十二指肠残端瘘, 胃手术, 危险因素, 诊治

Abstract: Duodenal stump fistula is a common and severe complication following gastrectomy, particularly prevalent after Billroth-Ⅱ and Roux-en-Y reconstruction. Clinical manifestations include epigastric pain, fever, and tachycardia, with severe cases progressing to life-threatening complications such as peritonitis, intra-abdominal infection, and shock. Diagnosis relies on imaging modalities, including CT and ultrasonography. Risk factors encompass age, sex, malnutrition, hypoalbuminemia, cirrhosis, as well as tumor location in gastric cancer. Notably, tumors involving the gastric antrum and pylorus are more prone to inducing stump fistula. Timely diagnosis and appropriate intervention are crucial for duodenal stump fistula. Mild cases may be managed solely with conservative treatment, such as fasting, gastrointestinal decompression, antibiotics, and nutritional support, while severe cases require surgical intervention. Endoscopic approaches are particularly beneficial for small, non-infected fistulas, offering a minimally invasive alternative to surgery, whereas open surgical intervention is reserved for advanced cases. Although the incidence of duodenal stump fistula is relatively low, improper management can lead to catastrophic outcomes. Therefore, tailored treatment plans based on individual patient profiles are essential to optimize therapeutic efficacy and improve prognosis.

Key words: duodenal stump fistula, gastric surgery, risk factors, diagnosis and treatment