关键词: 急性胰腺炎, 病因, 发病机制, 药物靶点, 临床转化, 临床试验

Abstract: Advancements in both basic and clinical translational research on acute pancreatitis        LIU Tao, LIU Yue-ze, ZHANG Tai-ping. Department of General Surgery, Peking Union Medical College Hospital，Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Corresponding author: ZHANG Tai-ping, E-mail: tpingzhang@
yahoo.com
Abstract    Acute pancreatitis (AP) is one of the common emergency cases in the department of general surgery with sudden onset and a high incidence of complications. Without timely intervention, it can progress to a critical condition and significantly affect the prognosis of patients. Currently, supportive care and surgery are the main treatment methods in the clinical practice, as there are no effective drugs available to reverse the development of AP. The pathogenesis of AP includes abnormal activation of trypsinogen, pathological calcium signaling, mitochondrial dysfunction, abnormal autophagy, endoplasmic reticulum stress, inflammation,immune regulation, etc. Based on this, a large number of studies have been conducted on the etiology, therapeutic targets, clinical transformation and clinical trials of AP, providing references for future clinical transformation.

Key words: acute pancreatitis, etiology, pathogenesis, drug targets, clinical translation, clinical trials