中国实用外科杂志

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围手术期补充性肠外营养支持治疗

朱明炜   

  1. 北京医院普外科  国家老年医学中心,北京100005
  • 出版日期:2018-03-01 发布日期:2018-03-06

  • Online:2018-03-01 Published:2018-03-06

摘要:

外科病人营养不良的发生率常较高,摄入不足和胃肠功能减退是主要原因,可导致术后并发症增加和住院时间延长,规范的营养支持治疗可改善临床结局。围手术期营养支持首选肠内营养(EN),以维护肠屏障和免疫功能,耐受性问题是导致EN难以实施或供给不足的主要原因,较长时间能量和蛋白质供给不足可导致病死率和并发症发生率升高,补充性肠外营养(PN)的核心是在EN的基础上联合PN,既维护肠屏障功能,又能较快到达目标喂养量,满足机体代谢需求,进而达到改善临床结局的目标。围手术期补充性PN的对象是EN不能满足60%以上能量需求的病人,低营养风险筛查2002(NRS2002)评分≤3分或危重症病人营养风险(NUTRIC)评分≤5分病人建议术后7 d启动;对于术前高营养风险(NRS2002评分≥5分或NUTRIC评分≥6分),术后48~72 h开始。补充性PN处方中添加谷氨酰胺和ω-3脂肪酸可优化外科病人临床结局,多腔袋的应用可减少血流感染,适合外科术后短期补充性PN病人。

关键词: 围手术期, 补充性肠外营养, 肠内营养

Abstract:

Perioperative supplementary parenteral nutrition support therapy        ZHU Ming-wei.Department of General Surgery, Beijing Hospital, National Center for Geriatrics, Beijing 100730,China
Abstract    The incidence of malnutrition is high in surgical patients. Inadequate intake and gastrointestinal dysfunction are the main causes, which can lead to increased postoperative complications and prolonged hospitalization. Standardized nutritional support can improve the clinical outcome. Enteral nutrition is preferred as perioperative support to protect the intestinal barrier and immune function. Intolerance is the main reason of enteral nutrition which is difficult to implement. The insufficient supply of energy and protein for longer periods of time can lead to increased mortality and complications. The combined with PN on the basis of EN is the core of parenteral nutrition which is to maintain intestinal barrier function, quickly reach the target amount to meet the metabolic needs and improve the clinical outcome. The target patient of perioperative parenteral nutrition is that enteral nutrition can not provide more than 60% energy needs. The start of enteral nutrition in patients with low nutrition risk (NRS2002 ≤3or Nutric score ≤ 5 ) will start after 7 days; and start at 48-72 hours after operation for high preoperative nutritional risk (NRS2002 ≥5 or Nutric score≥6). Supplement of parenteral nutrition with glutamine and ω-3 fatty acids can optimize the clinical outcomes of surgical patients. The application of multichamber bags can reduce bloodstream infections and is suitable for short-term supplementary parenteral nutrition after surgery.

Key words: perioperative, supplementary parenteral nutrition, enteral nutrition