关键词: 外周血管疾病, 血小板, 阿司匹林, 氯吡格雷

Abstract:

Clinical role and effect of antiplatelet therapy in peripheral vascular disease treatment        WANG Mian, CHANG Guang-qi. Department of Vascular Surgery, the First Affiliated Hospital of Sun Yat-sen University,Guangzhou510080,China
Corresponding author: CHANG Guang-qi, E-mail：changguangqi@yahoo.com.cn
Abstract    As economy growing and society aging, the incidence of peripheral vascular diseases (PVD) increases year after year. Platelet adhesion, activation and aggregation play pivotal steps in the process of PVD. Effective antiplatelet therapy could decrease the incidence of cardiovascular events in PVD patients significantly. Antiplatelet therapy for the secondary prevention could reduce the incidence of cardiovascular events in PVD patients with high risks effectively. However, reduced responsiveness to antiplatelet therapy is found in some patients and could increase risk of bleeding.

Key words: peripheral vascular disease, platelet, aspirin, clopidogrel