中国实用外科杂志

中国实用外科杂志 ›› 2011, Vol. 31 ›› Issue (10): 931-934.

• 专题笔谈 • 上一篇    下一篇

浸润性乳腺癌分子分型与辅助化疗方案选择

陈嘉健，柳光宇   

  1. 复旦大学附属肿瘤医院乳腺外科，上海 200032
  • 出版日期:2011-10-01 发布日期:2011-09-30

  • Online:2011-10-01 Published:2011-09-30

PDF

摘要：

随着基因表达谱与基因芯片技术的开展，乳腺癌在分子水平上表现出的高度异质性也逐渐受到关注。不同分子分型的乳腺癌，其流行病学危险因素、疾病自然进展过程以及对全身或局部治疗的反应性都不尽相同；对于乳腺癌的准确分型能够较为精确地反映肿瘤的生物学行为，对于判断预后、制定更具个体化的治疗策略具有深刻的意义。2011年的St.Gallen共识已针对不同的乳腺癌分子分型给出了原则性的治疗建议，标志着乳腺癌的治疗已逐步进入了在规范化多学科综合治疗模式的基础上，倡导个体化治疗的时代。

关键词: 浸润性乳腺癌, 分子分型, 辅助化疗

Abstract:

Invasive breast cancer molecular classification and the choice of adjuvant chemotherapy regimens        CHEN Jia-jian, LIU Guang-yu. Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Corresponding author: LIU Guang-yu, E-mail: liugy123@yahoo.com
Abstract    With the adoption and development of gene expression technique, the heterogeneity at the molecular level of the breast cancer has attracted attention gradually. The different breast cancer subtypes have different epidemiological risk factors, different natural histories and different responses to systemic and local therapies. To identify the exact subtype of the breast cancer has profound significance on making individualized therapies. The consensus of St. Gallen Breast Cancer Conference 2011 has provided different treatment suggestions according to different subtypes, which indicates that the management of breast cancer has entered the age of advocating individualized treatment on the basis of the standardization multi-disciplinary treatment gradually.

Key words: invasive breast cancer, molecular typing, adjuvant chemotherapy