中国实用外科杂志

中国实用外科杂志 ›› 2010, Vol. 30 ›› Issue (08): 695-697.

• 论著 • 上一篇    下一篇

妊娠相关乳腺癌5例临床诊治分析

王铭铭1，张军初2，徐昕昀2   

  1. 1浙江省慈溪市红十字医院乳腺外科，浙江慈溪315300；2第二军医大学附属长征医院普通外科，上海200003
  • 出版日期:2010-08-01 发布日期:2010-08-02

  • Online:2010-08-01 Published:2010-08-02

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摘要：

目的  探讨妊娠相关乳腺癌的诊断和治疗。方法  对第二军医大学附属长征医院1990-2006年收治的5例妊娠相关乳腺癌的临床及病理资料进行分析。结果  妊娠期发病3例、哺乳期发病2例。年龄23～37岁。所有病例术前均终止妊娠和哺乳，行乳腺癌根治术或改良根治术。术后病理报告均为浸润性导管癌，伴腋窝淋巴结转移。4例病人Cerb-2过度表达，有3例雌/孕激素受体均阴性。术后病理TMN分期Ⅱ期2例，Ⅲ期2例，Ⅳ期1例。5例病人术后均予化疗。术后随访有1例病人术后10年仍存活，余4例先后出现复发转移死亡。结论  妊娠相关乳腺癌因诊断晚，进展快，其预后较差。

关键词: 乳腺癌, 妊娠, 哺乳

Abstract:

Diagnostic and therapeutic management of breast cancer during pregnancy and lactation        WANG Ming-ming*, ZHANG Jun-chu, XU Xin-yun. *Department of Breast Surgery, Red Cross Hospital of Cixi City of Zhejiang Province, Cixi 315300, China
Corresponding author: WANG Ming-ming，E-mail: yang111zf@126.com
Abstract    Objective    To discuss the diagnostic and therapeutic management of breast cancer during pregnancy and lactation. Methods    The clinical and pathologic data of 5 patients with breast cancer during pregnancy and lactation admitted between 1990 and 2006 at Shanghai Changzheng Hospital were analyzed. Results    Of 5 patients, 3 patients were found during pregnancy and 2 patients were found during lactation. The ages ranged from 23 to 37. With termination of pregnancy ang lactation before operation, all of the patients underwent radical or modified mastectomy. Their postoperative pathology reports were infiltrating ductal carcinoma with axillary lymph node metastasis and positive Cerb-2 expression. ER/PR in 3 patients was negative. TNM stages included 2 patients in stageⅡ, 2 patients in stage Ⅲ and 1 patient in stage Ⅳ. Postoperative chemotherapy was given in all patients. One patient was still alive after 10 years and 4 patients died due to recurrence and metastasis during follow-up. Conclusion    Because of late diagnosis and rapid development, the prognosis of pregnancy-associated breast cancer is poor.

Key words: breast cancer, pregnancy, lactation