中国实用外科杂志

中国实用外科杂志 ›› 2010, Vol. 30 ›› Issue (04): 269-272.

• 专题笔谈 • 上一篇    下一篇

基因检测指导胃肠间质瘤治疗的价值

王雅杰   

  1. 第二军医大学长海医院肿瘤科，上海200433
  • 出版日期:2010-04-01 发布日期:2010-04-06

  • Online:2010-04-01 Published:2010-04-06

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摘要：

胃肠间质瘤（gastrointestinal stromal tumors，GIST）的发生与kit和PDGFR?α基因突变相关，有其独特的临床和病理特征。免疫组化的染色有助于GIST的诊断，而基因突变点的检测对临床应用伊马替尼和舒尼替尼治疗具有重要的指导意义。

关键词: 胃肠间质瘤, 基因检测

Abstract:

The clinical significance of mutation detection in the gastrointestinal stromal tumors        WANG Ya-jie. Department of Oncology, Changhai Hospital Attached to the Second Military Medical University,Shanghai 200433,China
Abstract    Gastrointestinal stromal tumor (GIST) is a specific clinicopathologic entity characterized by activating mutations of kit and PDFGR-αgenes. The immunohistochemical staining is frequently used to confirm the diagnosis. However, the demonstration of kit and PDFGR-α mutations has been shown to be more reliable in establishing the clinical significance for application of imatinib and sunitinib.

Key words: gastrointestinal stromal tumor (GIST), mutation detection