中国实用外科杂志

中国实用外科杂志 ›› 2012, Vol. 32 ›› Issue (10): 799-801.

• 院士论坛 • 上一篇    下一篇

转化医学与肝癌防治

郑树森，吴    健   

  1. 浙江大学医学院附属第一医院肝胆胰外科，浙江杭州310003
  • 出版日期:2012-10-01 发布日期:2012-09-28

  • Online:2012-10-01 Published:2012-09-28

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摘要：

基因组学、蛋白组学及代谢组学等技术应用带来肝癌基础研究的迅速发展，如何应用基础研究的成果提升临床诊疗水平，将基础研究指向临床面临的主要问题，是转化医学发展的主要目标。肝癌基因水平、表观基因水平、蛋白水平的变化，使发现新的分子生物学标记物成为可能，也提供了分子靶向治疗研究的新位点。过去以影像学为基础的肝癌肝移植选择标准也将转变为影像学与肿瘤生物学行为相结合。借助于我国丰富的肝癌临床资料，临床样本库已经成为转化医学体系的重要基础平台。

关键词: 转化医学, 肝癌, 肝移植

Abstract:

Translational medicine and the prevention and treatment of liver cancer        ZHENG Shu-sen，WU Jian. Department of Hepatobiliary and Pancreatic Surgery,  the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003,China
Corresponding author：ZHENG Shu-sen，E-mail：shusenzheng@zju.edu.cn
Abstract  The application of technologies like genomics，proteomics and metabonomics has given rise to the rapid development of basic research on the study of liver cancer. Yet，it remains a dilemma about how to apply the achievements of basic research to the clinical practice，which is also the main aim of the translational medicine. The variation at the gene，epigenetic and protein levels in liver cancer makes it possible to discover new molecular bio-markers and provide new insights into the study of target therapy. The selection criteria of liver transplant donors for liver cancer，which was based on the imaging previously，will also transform to the combination of imaging and biological behavior of tumors. Based on the abundant clinical data of liver cancer in China，it is important to establish the clinical sample bank to provide a platform for the translational medicine system.

Key words: translational medicine；liver cancer, liver transplantation