关键词: 胆道恶性肿瘤, 胆管癌, 胆囊癌, 指南, 解读

Abstract: Biliary tract cancer (BTC) has an extremely high malignance with a poor prognosis. Biliary tract cancers: French national clinical practice guidelines for diagnosis，treatments and follow-up was released in September 2023, and its English version was published in March 2024.This guideline are collaborative work written by a multidisciplinary committee comprising experts from different specialties involved in the management of BTCs. It summarized the evidence-based medical evidence for the diagnosis and treatment of BTCs before August 2023, and provided a detailed elaboration of the clinical practice for intrahepatic cholangiocarcinoma, gallbladder cancer, hilar cholangio-carcinoma, and distal bile duct cancer. The content covered epidemiology, diagnosis and classification, surgical treatment, medication, radiotherapy, and follow-up. This guideline emphasized the principles of individualized medicine and the importance of multidisciplinary involvement in BTCs practice. Of note, due to the limited number of high-quality clinical trials on BTCs, many clinical controversies remain unresolved. Therefore, a personalized therapeutic strategy for daily clinical practice should be provided based on the actual situation and the blind application of these guidelines should be avoided. Meanwhile, the controversies mentioned in the guidelines also indicated possible directions for future high-quality clinical research.

Key words: biliary tract cancer, cholangiocarcinoma, gallbladder cancer, guideline, interpretation