关键词: 肝内胆管癌, 肝移植, 肝切除, 多学科治疗

Abstract: Optimal management of multidisciplinary treatment for intrahepatic chaolangiocarcinoma        LIU Lian-xin, YIN Da-long. Department of Hepatobiliary Surgery, the First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China
Corresponding author：LIU Lian-xin,，E-mail：liulx@ustc.edu.cn
Abstract    Intrahepatic cholangiocarcinoma（ICC）is the second most common hepatic malignancy. Although radical R0 resection is the preferred treatment，only about 12% to 40% of the patients with ICC have the chance of radical surgery at the time of diagnosis. Current 5-year overall survival following liver resection is in the range of 25% to 40%. For locally advanced disease not amenable to upfront liver resection，neoadjuvant chemotherapy or locoregional therapies may be used with the aim of converting those patients to resectability or even to transplantation in well-selected cases. Molecular profiling of ICC is likely to provide improved prognostic assessment，more precise selection for surgical intervention and objective stratification of risk of recurrence to be counteracted by specifically designed adjuvant treatments such as targeting molecular and immunotherapy. The multi-disciplinary treatment should mainly focus on hepatobiliary surgeon，including specialist from radiology，pathology，oncology，radiotherapy and interventional department. The optimal option for ICC can be employed only through multi-disciplinary management based on the patient's individualized presentations.

Key words: intrahepatic cholangiocarcinoma, liver resection, liver transplantation, multidisciplinary treatment