关键词: 肝内胆管癌, 局部治疗, 消融治疗, 介入治疗, 放射治疗

Abstract: Local regional therapies for intrahepatic cholangiocarcinoma        CHEN Min-shan，FU Yi-zhen. Department of Liver Surgery，Sun Yat-sen University Cancer Center，Guangzhou 510060，China
Corresponding author：CHEN Min-shan，E-mail：chenmsh@
sysucc.org.cn
Abstract    Intrahepatic cholangiocarcinoma（ICC）is a kind of rare，highly aggressive primary liver cancer. There has been limited options for the treatment of ICC with surgical resection the only potentially curative choice. Local regional therapies（LRTs）consist of ablation，intra-arterial therapies（IATs）and radiotherapy. LRTs could be applied to the treatment of each stage of ICC. For early stage ICC patients who were not amenable for surgery，ablation might bring out comparable outcomes to surgery； for local advanced ICCs，LRTs reduced the tumor burden as well as provide symptomatic relief and had a positive effect on survival；and for patients underwent resection，adjuvant radiotherapy and transarterial chemoembolization may reduce the risk of tumor recurrence. Hence，the authors suggested that LRTs played essential roles in the multidisciplinary approaches to ICC.

Key words: intrahepatic cholangiocarcinoma, local regional therapy, ablation, intra-arterial therapy, radiotherapy