中国实用外科杂志

中国实用外科杂志

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肝癌术后复发风险预测及干预策略

陆伟东，李风伟，张小峰，李    俊，王    葵，沈    锋   

  1. 海军军医大学东方肝胆外科医院，上海 200438
  • 出版日期:2019-10-01 发布日期:2019-10-10

  • Online:2019-10-01 Published:2019-10-10

摘要：

肝细胞癌是世界上最常见的恶性肿瘤之一，肝切除术和肝移植是其最重要的治疗方法，但术后肿瘤的高复发率显著降低了长期存活率。微血管侵犯（MVI）可预测术后肿瘤复发的风险，是肝切除术后复发的独立危险因素。临床应重点关注如何制定经组织病理学检查证实MVI的肝细胞癌病人的术后抗复发措施，以及应用预测模型指导外科治疗方法的个体化选择，明确复发预防重点对象，提高抗复发的效率。

关键词: 肝细胞癌, 术后复发, 预测, 干预

Abstract:

Prognosis and intervention strategy for postoperative recurrence of hepatocellular carcinoma        LU Wei-dong，LI Feng-wei，ZHANG Xiao-feng，et al. Department of Hepatic Surgery，Eastern Hepatobiliary Surgical Hospital，Naval Medical University，Shanghai 200438，China
Corresponding author：SHEN Feng，E-mail：shenfengehbh@ sina.com
Abstract    Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. Liver resection and transplantation are currently the most important treatments，but the high recurrence rate of postoperative tumors significantly reduces long-term survival. Microvascular invasion (MVI) predicts the risk of postoperative tumor recurrence and is an independent risk factor for recurrence after resection. Furthermore，focusing on how the postoperative management can be improved on histopathologically confirmed patients with HCC with MVI，and the potential roles of using predictive tests to estimate the risk of presence of MVI，help in preoperative therapeutic decision-making in patients with HCC. 

Key words: hepatocellular carcinoma, postoperative recurrence, prognosis, intervention