关键词: 胃肠间质瘤, 外科手术

Abstract:

Surgical management of gastrointestinal stromal tumor             LIANG Han. Department of Gastrointestinal Oncological Surgery, Tianjin Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laborary of Cancer Prevention and Therapy, Tianjin 300060, China
Abstract    The principle of surgical treatment of gastrointestinal stromal tumor (GIST) is removing the tumor as completely as possible (R0). The majority of gastric stromal tumor can be removed with local or wedge excision. Proximal gastrectomy is a choice for  stromal tumor locating at the cardia since local resection may cause cardia stenosis. Distal gastrectomy is suitable for stromal tumor locating at lesser curvature of gastric antrum. Total gastrectomy is rare for gastric stromal tumor. Combined spleen, tail of pancreas and transverse colon resection may necessary for R0 surgery of greater curvature of gastric antrum. Local resection is the first choice for duodenal stromal tumor. Operation procedure must be carried out carefully for small intestinal stromal tumor in order to avoid tumor rupture. Combined resection is a right choice when tumor involved surrounding organs or structure. In principle, low anterior instead of abdominoperineal resection is the only recommend procedure for rectal stromal tumor. Selected patients with recurrence or metastatic GIST who have controlled disease to TKI therapy can benefit from surgical resection.

Key words: gastrointestinal stromal tumor, surgery