关键词: 液体治疗, Starling原理, 多糖蛋白

Abstract:

Significance of the Starling’s principle in the fluid therapy        LI Jian-guo. Department of Intensive Care Unit，Zhongnan Hospital of Wuhan University，Wuhan 430071，China
Abstract    Fluid therapy is a ubiquitous intervention in critical care medicine. For decades，clinicians have made their selection of resuscitation fluids based on the Starling’s principle, describing two opposing forces across the endothelial cell line to maintain compartments in balance. Recent descriptions have questioned the classic models. A web of membrane-bound glycocalyx on the luminal side of endothelial cells has been identified as the endothelial surface layer. The carrier of vascular barrier competence is the intact endothelial surface layer and the subglycocalyx space produces a colloid oncotic pressure that is an important determinant of transcapillary flow.  The classic Starling’s principle must be reevaluated，this has new influence on the liquid treatment.

Key words: fluid therapy；Starling&rsquo, s principle；endothelial glycocalyx