关键词: 高渗盐水, 液体复苏, 全身炎性反应综合征

Abstract:

Hypertonic saline in surgical patients’ fluid resuscitation          ZHANG Tai-ping，SHEN Peng，ZHAO Yu-pei. Department of General Surgery，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences，Beijing 100730，China
Corresponding author：ZHAO Yu-pei，E-mail：zhao8028@126.net
Abstract    Due to factors such as surgical trauma，the postoperative patients will suffer water，electrolyte and acid-base balance disorder，and release a large number of inflammatory mediators，which can cause systemic vascular endothelial cell injury，and eventually result in systemic inflammatory response syndrome（SIRS），capillary leak syndrome（CLS），and even hypovolemic shock. Lots of animal experiments and clinical studies have shown that hypertonic saline can improve the outcomes of patients with its hypertonicity and play a role in inflammation in the process of the fluid resuscitation treatment. But the best dose of hypertonic saline，its compatibility with other solutions，and how to reduce the adverse reactions still need further research.

Key words: hypertonic saline, fluid resuscitation, systemic inflammatory response syndrome