中国实用外科杂志

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生物制剂时代营养治疗在克罗恩病治疗中的价值及评价

贡钰霞,朱维铭   

  1. 南京中医药大学附属医院炎症性肠病诊疗中心,江苏南京 210029 
  • 出版日期:2024-02-01

  • Online:2024-02-01

摘要: 克罗恩病(CD)主要累及胃肠道,影响营养的消化吸收,因此营养治疗一直是CD的重要手段,并可能伴随疾病的始终。生物制剂的问世在CD治疗中具有划时代的意义。近二十年,生物制剂的广泛应用显著提高了CD的治疗效果。营养治疗不但能够纠正营养不良,还能够诱导CD缓解,并提高生物制剂的治疗效果;营养治疗还是CD围手术期最重要的治疗手段,甚至在CD合并感染时作为生物制剂和免疫抑制剂的替代治疗手段,发挥治疗作用。

关键词: 克罗恩病, 营养治疗, 生物制剂, 预康复

Abstract: Value and evaluation of nutritional therapy in the treatment of Crohn's disease in the era of biologics                     GONG Yu-xia, ZHU Wei-ming. Inflammatory Bowel Disease Diagnosis and Treatment Center of Nanjing University of Traditional Chinese Medicine Affiliated Hospital, Nanjing 210029, China
Corresponding author: ZHU Wei-ming, E-mail:yfy135@
njucm.edu.cn
Abstract    Crohn’s disease(CD) primarily affects the gastrointestinal tract and causes disturbances in the digestion and absorption of nutrients. Therefore, nutritional therapy remains a crucial tool for the management of CD, potentially accompanying the disease throughout its course. The introduction of biological agents in CD treatment has had a groundbreaking impact. Over the past two decades, the broad application of biological agents has significantly enhanced the therapeutic outcomes for Crohn's disease. Nutritional therapy corrects malnutrition, induces CD remission, and improves biologics' therapeutic effect. Additionally, it serves as the most important therapeutic means during the perioperative period of CD and can even act as an alternative therapy to biologics and immunosuppressants when CD is complicated with infections.

Key words: Crohn’s disease, nutritional therapy, biologics, rehabilitation