关键词: 乳腺癌, 肿瘤微环境, 内分泌治疗, 耐药

Abstract: Research progress of the role of tumor microenvironment in endocrine therapy resistance in hormone-positive breast cancer        YUAN Jie*，LUO Cheng-yu. *Department of General Surgery，Beijing Anzhen Hospital，Capital Medical University，Beijing 100029，China；Department of Endocrine and Vascular Surgery, Taihe Hospital, Hubei University of Medicine, Hubei 442000, China
Corresponding author：LUO Cheng-yu，E-mail：luochengyu@163.com
Abstract    Complex communications exist between cells and cells，as well as between cells and non-cellular components in tumor microenvironment，inducing the production of cytokines, growth factors and MMPs，which is involved in tumor immune escape and ECM remodeling，leading to drug resistance to endocrine therapy of breast cancer. Therefore，tumor microenvironment may be the key to evaluate tumor development direction and overcome drug resistance to treatment. Treatment targeting the tumor microenvironment (such as immunotherapy) at the early stage of the tumor may reduce the occurrence of tumor micrometastases and thus reduce the long-term recurrence of ER-positive breast cancer. In addition，the current therapies for hormone receptor-positive advanced breast cancer are all targeting tumor cells，and regulating the interaction between tumor microenvironment and tumor cells may become a new direction to solve the problem of drug resistance to endocrine therapy.

Key words: breast neoplasms, tumor microenvironment, endocrine therapy, resistance