关键词: 肿瘤超进展, 系统治疗, 肝癌

Abstract: Recent advance in tumor hyperprogression in systemic therapy of liver cancer        XU Lei, ZHANG Wan-guang.Liver Surgery Center, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Corresponding author：ZHANG Wan-guang, E-mail:wgzhang@
tjh.tjmu.edu.cn
Abstract    With the rapid development of systemic treatment in liver cancer，targeted therapy and immunotherapy have been widely performed in advanced and recurrent liver cancer. Tumor hyperprogression is a phenomenon of accelerated tumor growth，which occurs in patients with solid tumors such as liver cancer who have received systematic treatment，and is mainly related to immunotherapy. At present，the understanding of tumor hyperprogression in liver cancer is insufficient for the lack of relevant clinical studies，so it is difficult to predict the occurrence and severity of tumor hyperprogression.

Key words: hyperprogressive disease, systemic therapy, liver cancer