关键词: 肝细胞癌, 转化治疗, 降期

Abstract:

Advances and evaluation of main patterns of conversion therapy for initially unresectable primary liver cancer               ZHOU Jian, XIAO Yong-sheng, LI Hui. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Corresponding author：ZHOU Jian, E-mail:zhou.jian@zs-hospital.sh.cn
Abstract    Primary liver cancer is one of the malignant tumors with the highest mortality rate in China，and hepatic resection is the main optimal curative treatment. However，most patients with liver cancer have lost the opportunity of hepatic resection when they are diagnosed. Therefore，how to convert unresectable tumor into resectable state will become an important direction for liver cancer clinical research. In recent years，conversion therapy for liver cancer has undergone tremendous changes，and new therapeutic methods and drugs have emerged one after another. In the future，how to accurately select liver cancer patients suitable for conversion therapy，rationally select conversion therapy plans，and accurately determine the timing of surgery after conversion therapy are major challenges faced by hepatobiliary surgeons. There is an urgent need to carry out high-quality clinical randomized controlled trials to provide higher-level evidence-based medicine, which is expected to form a new standard for conversion therapy of liver cancer with Chinese characteristics.

Key words: hepatocellular carcinoma, conversion therapy, downstaging