中国实用外科杂志

中国实用外科杂志

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基于SEER数据库的甲状腺髓样癌诊治相关研究进展

王志宏，桂志强，张    浩   

  1. 中国医科大学附属第一医院甲状腺外科，辽宁沈阳110001
  • 出版日期:2020-09-01 发布日期:2020-09-21

  • Online:2020-09-01 Published:2020-09-21

摘要： 甲状腺髓样癌（MTC）起源于甲状腺滤泡旁细胞，恶性程度介于分化型甲状腺癌与未分化癌之间，具有侵袭性强、预后差、早期向颈部淋巴结转移或远处转移的特点。2015年美国甲状腺协会（ATA）发布的指南中建议将全甲状腺切除及预防性中央区淋巴结清扫作为甲状腺髓样癌手术治疗的标准方式。由于各中心缺少足够大的样本量，在探究MTC这一特殊类型甲状腺恶性肿瘤的预后及诊治进展上存在争议。利用美国国家癌症研究所“监测、流行病学和最终结果”（SEER）数据库，运用大样本数据得出可供临床参考的更具可信度的结论。

关键词: 甲状腺髓样癌, 监测、流行病学和最终结果数据库, 研究进展, 综述

Abstract: Progress in diagnosis and treatment of medullary thyroid carcinoma based on SEER database        WANG Zhi-hong, GUI Zhi-qiang, ZHANG Hao. Department of Thyroid Surgery, the First Hospital of China Medical University,Shenyang 110001, China
Corresponding author：WANG Zhi-hong,E-mail：wangzhihongcmu@163.com
Abstract    Medullary thyroid carcinoma（MTC）originates from parafollicular cells，and its malignant degree is between differentiated thyroid carcinoma and anaplastic thyroid carcinoma. Medullary thyroid carcinoma has the characteristics of strong invasiveness，poor prognosis，early metastasis to cervical lymph nodes，and distant metastasis.In 2015，the guidelines issued by the American Thyroid Association（ATA）recommended total thyroidectomy and prophylactic central lymph node dissection as the standard surgery for treatment of medullary thyroid carcinoma. Owing to the lack of sufficient sample size in each center，it is controversial to explore the prognosis，diagnosis，and treatment of MTC，a special type of thyroid malignant tumor. Using the Surveillance，Epidemiology，and End Results（SEER）database of the National Cancer Institute，a larger sample of data is utilized to draw more reliable conclusions for clinical reference.

Key words: medullary thyroid carcinoma；Surveillance, Epidemiology, and End Results（SEER）；research progress；review