关键词: 局部晚期肝内胆管癌, 新辅助治疗, 化疗, 局部治疗, 肝移植

Abstract: Controversy and consensus on neoadjuvant therapy for intrahepatic cholangiocarcinoma        ZHANG Yan-qiao，ZHENG Tong-sen.  Department of Gastrointestinal Medical Oncology，Harbin Medical University Cancer Hospital; Gastrointestinal Cancer Diagnosis and Treatment Center of Heilongjiang Province, Harbin 150081，China
Corresponding author：ZHANG Yan-qiao，E-mail：yanqiaozhang@126.com
Abstract    Intrahepatic cholangiocarcinoma（ICC）has occult symptoms and is lack of specific clinical manifestations in the early stage. Due to the lack of effective screening，ICC is mostly in the advanced stage when diagnosed，and the opportunity for surgical resection is lost. Radical surgery is still the only treatment that can provide patients with long-term survival，but there is a low rate of radical resection. And it is easy to relapse after surgery. Neoadjuvant therapy can reduce the original focus and metastatic lymph nodes，and improve the rate of R0 resection. For unresectable locally advanced ICC，neoadjuvant therapy can reduce the locally advanced ICC to be resectable and can also improve the prognosis of patients with liver transplantation. However，the potential utility of neoadjuvant therapy in ICC is still controversial.

Key words: locally advanced intrahepatic cholangiocarcinoma, neoadjuvant therapy, chemotherapy, local treatment, liver transplantation