中国实用外科杂志

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肝癌肝切除术式选择的共识与争议

荚卫东,陈    浩   

  1. 中国科学技术大学附属第一医院 安徽省立医院肝脏外科 肝胆胰外科安徽省重点实验室,安徽合肥230001
  • 出版日期:2018-04-01 发布日期:2018-03-30

  • Online:2018-04-01 Published:2018-03-30

摘要:

肝切除依然是目前肝细胞癌主要的治疗方式之一,切除方式包括解剖性肝切除和非解剖性肝切除。由于目前相关的临床研究均为回顾性研究,缺乏随机对照试验,临床实践中究竟是选择解剖性肝切除还是非解剖性肝切除,尚存在争议。肝癌肝切除的成功依赖于肿瘤根治性切除和剩余肝脏功能之间的精准平衡。解剖性肝切除的优势在于完整切除荷瘤肝段(叶),同时将供应荷瘤肝段(叶)的门静脉系统完整移除,从而最大限度地减少亚临床转移灶,减少肿瘤残留和术后复发,改善长期生存。非解剖性肝切除仅对切缘阴性范围有要求,能够较好地保留无瘤的功能性肝脏组织。综合评估肝脏储备功能和肿瘤相关因素,兼顾手术的安全性和彻底性,将有助于选择合适的手术切除方式。

关键词: 肝细胞癌, 解剖性肝切除, 非解剖性肝切除

Abstract:

Controversy and consensus on the choice of hepatectomy for hepatocellular carcinoma        JIA Wei-dong,CHEN Hao. Department of Hepatic Surgery,Anhui Provincial Hospital; Key Laboratory of Hepatopancreatobiliary Surgery of Anhui Province,Hefei 230001,China
Corresponding author:JIA Wei-dong,E-mail:jwd1968@sina.com
Abstract    Liver resection is still one of the main treatment of hepatocellular carcinoma,the methods of resection include anatomical liver resection and non-anatomical liver resection. Because of the current clinical studies are all retrospective study,lack of randomized controlled trials,there is still controversial of the choice of anatomical or non-anatomical liver resection in clinical practice. Successful hepatectomy for hepatocellular carcinoma depends on the precise balance between radical tumor resection and residual liver function. Anatomical liver resection has the advantage of complete resection of tumor-burdened liver segment (or leaf),at the same time will remove the tumor-burdened liver segment (or leaf) and its portal vein system completely,thus minimizes the sub-clinical metastases,reduces the residual and postoperative recurrence of the tumor,and improves the long-term survival rate of hepatocellular carcinoma patients. Non-anatomical liver resection needs the enough negative cut edge,it can retain the disease-free functional liver tissue well. Comprehensive evaluation of liver reserve function and tumor-related factors,taking into account the safety and thoroughness of surgery,will help to select the appropriate surgical resection.

Key words: hepatocellular carcinoma;anatomical liver resection;non-anatomical , liver resection