关键词: 胃肠间质瘤, 美国国家综合癌症网络, 指南

Abstract:

Updates and interpretations of the NCCN Clinical Practice Guidelines (2017 second version) on gastrointestinal stromal tumor        WANG Ming, CAO Hui. Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Corresponding author: CAO Hui, E-mail: caohuishcn@hotmail.com
Abstract    The diagnosis and treatment of gastrointestinal stromal tumor （GIST） is getting more and more standardized. In the last decade，due to the revelation of the molecular mechanism of its tumorigenesis，as well as the effectiveness of tyrosine kinase inhibitors，GIST has become well known as one of the most classical models of targeted therapy on solid tumor in the precision medicine era. The National Comprehensive Cancer Network （NCCN） issued the latest version of clinical practice guideline on GIST in Feb. 2017. The updated guideline standardized the principle of imaging and updated the predictor of GIST biological behavior. Given the newly emerged evidence from clinical trials，in the discussion chapter，the updated guideline also highlighted the prognostic value of mutational characteristics and the role of laparoscopic surgery in the treatment of GIST. The paper provides interpretations of the updates，aiming to improve the clinical practice of GIST.

Key words: gastrointestinal stromal tumor, National Comprehensive Cancer Network, guideline